2. Signaling Pathways
  3. GPCR/G Protein
    Neuronal Signaling
  4. Melanocortin Receptor

Melanocortin Receptor

MC Receptor

Melanocortin Receptor

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The melanocortin (MC) receptors represent a subfamily of G-protein-coupled receptors (GPCRs) where the different subtypes are involved in a wide range of physiological functions such as pigmentation, steroid secretion, energy homeostasis, and food intake. The melanocortin receptor (MCR) family consists of five G-protein-coupled receptors (MC1R-MC5R). MC1R controls pigmentation, MC2R is a critical component of the hypothalamic-pituitary-adrenal axis, MC3R and MC4R have a vital role in energy homeostasis and MC5R is involved in exocrine function.

MCRs are activated by a variety of neuropeptides, termed melanocortins, that include the adrenocorticotropic hormone (ACTH) andα, β and γ-melanocyte-stimulating hormones (MSHs). Melanocortins derive from post-translational processing of the common polypeptide precursor pro-opiomelanocortin, expressed mainly in the hypothalamus and pituitary.

Melanocortin Receptor Isoform Specific Products:

Melanocortin Receptor Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-P1503
    ACTH (4-11)
    		98.48%
    ACTH (4-11), an adrenocorticotropin hormone fragment, possesses a weak α-melanocyte stimulating hormone (α-MSH) potency only at high doses (100 and 1000 nM).
    ACTH (4-11)
  • HY-P11280A
    PRAME peptide (425-433) acetate
    		Degrader 98.16%
    PRAME peptide (425-433) acetate is a proteasome-degraded peptide derived from the cancer-testis antigen PRAME (Preferentially Expressed Antigen in Melanoma). PRAME peptide (425-433) acetate is restricted by HLA-A*02:01 and can serve as a target for bispecific T cell engager therapy in the context of major histocompatibility complex I presentation. PRAME peptide (425-433) acetate shows application potential in various malignant tumors and is widely suitable for research related to solid tumors, melanoma, ovarian cancer, endometrial cancer, and lung cancer (including lung adenocarcinoma and lung squamous cell carcinoma). PRAME peptide (425-433) acetate can be used to explore disease of triple-negative breast cancer, diffuse large B-cell lymphoma, and head and neck squamous cell carcinoma.
    PRAME peptide (425-433) acetate
  • HY-P1739
    ACTH (34-39)
    		99.88%
    ACTH (34-39) is an adrenocorticotropic hormone fragment. ACTH (34-39) can be used in the study of stress-related sleep disorders.
    ACTH (34-39)
  • HY-P1558A
    ACTH (11-24) acetate
    		Antagonist 99.88%
    ACTH (11-24) (acetate) is an adrenocorticotropic hormone (ACTH) receptor antagonist. ACTH (11-24) is a fragment of adrenocorticotropic and induces cortisol release. ACTH (11-24) can be used for the research of central nervous system.
    ACTH (11-24) acetate
  • HY-P1518
    Adrenocorticotropic Hormone (ACTH) (1-10), human
    		98.26%
    Adrenocorticotropic Hormone (ACTH) (1-10), human, an adrenocorticotropin hormone fragment, possesses a weak α-melanocyte stimulating hormone (α-MSH) potency only at high doses (100 and 1000 nM).
    Adrenocorticotropic Hormone (ACTH) (1-10), human
  • HY-P4665
    Ac-c[Cys-Glu-His-d-Phe-Arg-Trp-d-Cys]-Pro-Pro-Lys-Asp-NH2
    		Antagonist 98.14%
    Ac-c-Pro-Pro-Lys-Asp-NH2 is a selective human melanocortin 5 receptor (hMC5R) antagonist with an IC50 of 10 nM.
    Ac-c[Cys-Glu-His-d-Phe-Arg-Trp-d-Cys]-Pro-Pro-Lys-Asp-NH2
  • HY-148349A
    (2R,2R)-PF-07258669
    		Antagonist 99.64%
    (2R,2R)-PF-07258669 is a MC4R (melanocortin 4 receptor) antagonist. (2R,2R)-PF-07258669 can be used in the study of regulating appetite and energy expenditure.
    (2R,2R)-PF-07258669
  • HY-P3645
    (Nle4)-α-MSH
    		Agonist
    (Nle4)-α-MSH is a synthetic analogue of α-MSH (HY-P0252), a melanocyte-stimulating hormone. (Nle4)-α-MSH reversibly darkens frog skins and also exhibits prolonged activity after heat-alkali treatment.
    (Nle4)-α-MSH
  • HY-P1869
    Neuropeptide EI, rat
    		Agonist
    Neuropeptide EI, rat displays functional melanin concentrating hormone (MCH)-antagonist and melanocyte-stimulating hormone (MSH) agonist activity in different behavioral paradigms.
    Neuropeptide EI, rat
  • HY-P3981
    Defensin NP-3A
    		Inhibitor
    Defensin NP-3A (NP-3A; Corticostatin 1) is a human granulocyte peptide, with anti-ACTH activity. Defensins are antimicrobial peptides with and cytotoxic activity.
    Defensin NP-3A
  • HY-P3659
    (D-Phe7)-α-MSH
    (D-Phe7)-α-MSH is an α-MSH analogue.
    (D-Phe7)-α-MSH
  • HY-N0637AR
    (±)-Eriodictyol (Standard)
    3-Chlorobenzoic acid (Standard) is the analytical standard of 3-Chlorobenzoic acid. This product is intended for research and analytical applications. (±)-Eriodictyol ((±)-Huazhongilexone; Dihydroluteolin) is an orally active TRPV1 receptor antagonist (IC50=44-47 nM, rTRPV1) with antioxidant and anti-inflammatory activities. (±)-Eriodictyol effectively inhibits lipid peroxidation and the release of proinflammatory cytokines by specifically antagonizing the TRPV1 receptor and activating the Nrf2 signaling pathway. (±)-Eriodictyol reduces the levels of ICAM-1, VEGF, eNOS and TNF-α in the retina and maintains the integrity of the blood-retinal barrier. (±)-Eriodictyol alleviates oxidative stress-induced apoptosis and hyperalgesia, enhances the activity and cytotoxicity of immune cells (such as B lymphocytes, NK cells and macrophages), and increases the levels of antioxidant enzymes simultaneously. (±)-Eriodictyol can be used in the research of diabetic retinopathy, acute lung injury and various pain-related diseases.
    (±)-Eriodictyol (Standard)
  • HY-RS08210
    Mc4r Mouse Pre-designed siRNA Set A
    		Inhibitor

    Mc4r Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mc4r gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Mc4r Mouse Pre-designed siRNA Set A
  • HY-P3979
    Defensin HNP 4
    		Inhibitor
    Defensin HNP 4 (HNP 4) is a host-defense peptide that has antimicrobial activity against Gram-negative bacteria. Defensin HNP 4 inhibits ACTH stimulated synthesis of Corticosterone (HY-B1618) in rat adrenal cell suspensions.
    Defensin HNP 4
  • HY-N0998
    1,7-Bis(4-hydroxyphenyl)-hepta-4E,6E-dien-3-one
    		Inhibitor
    1,7-Bis(4-hydroxyphenyl)-hepta-4E,6E-dien-3-one (compound 6) shows antiproliferative activity with ED50s of 57.7, 78.8 μM for 26-L5 and HT-1080 cells, respectively. 1,7-Bis(4-hydroxyphenyl)-hepta-4E,6E-dien-3-one inhibits melanogenesis in B16 melanoma 4A5 cells. 1,7-Bis(4-hydroxyphenyl)-hepta-4E,6E-dien-3-one has the potential for the research of skin disorders.
    1,7-Bis(4-hydroxyphenyl)-hepta-4E,6E-dien-3-one
  • HY-109114A
    Dersimelagon phosphate
    		Agonist
    Dersimelagon phosphate is an orally active, selective melanocortin 1 receptor (MC1R) agonist with EC50 values of 8.16, 3.91, 1.14 and 0.251 nM for human (h), cynomolgus monkey (cm), mouse (m) and rat (r) MC1R, respectively. Dersimelagon phosphate shows good affinity for hMC1R and hMC4R with Ki values of 2.26, 32.9 nM, respectively. Dersimelagon phosphate can be used for the research of skin pigmentation.
    Dersimelagon phosphate
  • HY-P11238
    Filimelnotide
    		Agonist
    Filimelnotide is a agonist of melanocortin receptor.
    Filimelnotide
  • HY-RS08200
    MC1R Human Pre-designed siRNA Set A
    		Inhibitor

    MC1R Human Pre-designed siRNA Set A contains three designed siRNAs for MC1R gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    MC1R Human Pre-designed siRNA Set A
  • HY-N1002
    Cadin-1(14)-ene-7a,11-diol
    		Inhibitor
    Cadin-1(14)-ene-7a,11-diol is a sesquiterpene alcohol with melanogenesis inhibitory activity. Cadin-1(14)-ene-7a,11-diol inhibits the melanogenesis in B16 melanoma cells induced with α-MSH (HY-P0252). Cadin-1(14)-ene-7a,11-diol can be used as a potential skin-whitening agent.
    Cadin-1(14)-ene-7a,11-diol
  • HY-RS08212
    MC5R Human Pre-designed siRNA Set A
    		Inhibitor

    MC5R Human Pre-designed siRNA Set A contains three designed siRNAs for MC5R gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    MC5R Human Pre-designed siRNA Set A
Cat. No. Product Name / Synonyms Application Reactivity
Melanocortin Receptor Isoform Comparison

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